Inhalation therapy

PARI's mission

Improving the lives of those affected by respiratory diseases

We've been pioneering healthcare improvements for over 100 years, and have built a reputation for delivering innovation and quality. Guided by a world-class research lab, we develop products that continually advance the science of respiratory care. At PARI we approach the future with the expertise necessary to adapt to a changing healthcare market in an effort to improve the lives of those affected by respiratory diseases.

Inhalation Systems

Our inhalation devices provide an effective and gentle way of treating respiratory disease.

Advantages of nebulizer therapy

Advantages of nebulizer therapy

Simple, suitable for every age, and can be combined with airway clearance therapy to save time.

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Metered-dose inhalers, dry powder inhalers, and nebulizer systems.

These devices, which have different methods of administration, indications and modes of action, are recommended for inhalation therapy based on the disease, the age of the patient and the patient’s needs.

  • PARI jet nebulizers and vibrating membrane nebulizers meet a wide range of respiratory needs and deliver important medications and saline solutions to treat various respiratory conditions such as Asthma, COPD, Cystic Fibrosis and NTM (non-tuberculous mycobacterium disease).
  • Valved holding chambers (VHC), more commonly called spacers are recommended with MDI's to overcome the difficulty some people have with the inhalation technique that is needed with MDIs. VHCs also minimize potential side effects in the mouth that may occur when MDIs are used alone because more drug deposits in the mouth than the lungs.1


Inhalation systems: what's the difference?1

Advantages of Nebulizers

  • Ability to aerosolize many drug solutions
  • Minimal patient coordination is needed
  • Useful in very young, very old, debilitated, or distressed patients
  • Normal breathing pattern can be used, and an inspiratory pause (breath-hold) is not required for efficacy

Disadvantages of Nebulizers

  • Treatment times vary depending on the type of nebulizer
  • Need for power source (electricity, battery, or compressed gas)
  • Potential for drug delivery exposure to clinicians and caregivers
  • Assembly and cleaning are required
  • Contamination is possible with improper handling of drug and inadequate cleaning
  • Variability in performance characteristics among different types, brands, and models

Advantages of Metered Dose Inhalers (MDIs)

  • Portable, light, and compact
  • Short treatment time
  • No drug preparation required

Disadvantages of Metered Dose Inhalers (MDIs)

  • Hand-breath coordination required
  • Patient activation, proper inhalation pattern, and breath-hold required
  • Reaction to propellants in some patients
  • High oropharyngeal deposition
  • Difficult to determine the dose remaining in the canister without dose counter

Advantages of Valved Holding Chamber or Spacers with MDIs

  • Reduced oropharyngeal drug impaction and loss
  • Increased inhaled drug by two or four times than the MDI alone
  • Simplifies coordination of MDI actuation and inhalation
  • Helps reduce local and systemic side effects

Disadvantages of Valved Holding Chamber or Spacers with MDIs

  • Larger in size compared to MDI alone
  • Not always covered by insurance
  • Possible contamination with inadequate cleaning

Advantages of Dry Powder Inhalers (DPIs)

  • Small and portable
  • Built-in dose counter
  • Propellant free
  • Breath-actuated

Disadvantages of Dry Powder Inhalers (DPIs)

  • Dependence on patient’s inspiratory flow
  • Patient less aware of delivered dose
  • Relatively high oropharyngeal impaction
  • Vulnerable to ambient humidity or exhaled humidity into mouthpiece
  • Limited range of drugs
  • Different DPIs with different drugs
  • Easy for patient to confuse directions for use with other devices
Not all nebulizers are equal

Not all nebulizers are equal

There are many parameters we can use to compare the quality and efficiency of nebulizers. These parameters are especially important for the success of your therapy.

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How to use a nebulizer

How to use a nebulizer

Using a nebulizer is easy: Sit comfortably and use normal, relaxed breathing to inhale the aerosol.

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Proven benefits of Aerosol Therapy

Aerosol therapy is an important treatment for people that are living with respiratory disease. Taking medications via nebulizer has been shown in numerous studies to benefit people with respiratory disease.

Why is aerosol droplet size so important in aerosol therapy?

Aerosol droplets (sometimes called particles) must be a certain size so that the medication can reach the lungs and do its intended job.

  • To reach the throat, nose and larynx during inhalation, large droplet sizes are needed.
  • Smaller droplets are needed to treat the lungs.
  • The deeper the aerosol has to travel in the lungs, the smaller the droplets need to be.
  • To reach into the sinuses, a pulsating aerosol is required.

Finding the right Inhalation Device

Our product guide helps you find the right device for you, fast.

To the Product Guide

1Gardenshire D. et al. A Guide to Aerosol Delivery Devices for Respiratory Therapists, 4th Edition. American Association for Respiratory Care, 2017:29.

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