Technology and
Platform

As our partner –

you will get an optimized, drug specific nebulizer

Customized, drug-specific eFlow^®Technology nebulizers are used for the treatment of lower respiratory tract diseases or for non-systemic drug delivery.

They are based on the eFlow^® Technology platform whose core consists of the aerosol head with the vibrating membrane. The nebulizers are characterized by high efficiency and short nebulization times (according to the properties of the drug to be nebulized) as well as high pulmonary deposition of the generated aerosols.

eFlow^® Technology nebulizers are specifically tailored to the requirements of certain drug formulations and patient groups. They are usually marketed exclusively as drug-device combination product under license by our pharmaceutical partners.

Optimized eFlow^® Technology nebulizers provide …

Fast inhalation with low dependence on the patients’ breathing patterns
Efficiency – high percentage of the filled volume can reach the lungs
Deposition of the drug in the deep lungs is possible
Optimized performance with low development efforts and short lead times
Easy setup in clinical trials with varying doses
Reduced risk in clinical development

The unique and customizable eFlow features and their advantages

Aerosal chamber
(with inspiratory/expiratory valve)

» Stores the continuously generated aerosol during exhalation

» Reduces losses during exhalation

» Produces a bolus effect – a large amount of aerosol is delivered to the patient right at the beginning of the inhalation

» Reduces inter-patient dose variability, e.g., less dependent on inter-patient differences in dead-space volume or breathing maneuvers

Vibrating membrane
(eFlow® Technology)

» Ensures high fine particle fraction

» Ensures high output rate

» Ensures proven reproducible aerosol performance

» Is easy and fast adjustable for a specific formulation

Medication reservoir

» No residual volume

» Allows a wide range of filling volumes

The Bolus Effect is generated by the aerosol chamber and enables reduced nebulization times and an increased drug delivery efficiency.

Nebulization of a broad variety of formulations

Aerosolisation of a broad variety of formulations

eFlow^® Technology nebulizers can be adjusted to a variety of molecules and formulations with a broad range of fill volumes and physicochemical properties, including:

Small molecules (e.g., glycopyrrolate, tobramycin, levofloxacin and others)
Protein formulations (e.g., alpha-1-antitrypsin)
Peptides (lonodelestat)
Oligonucleotides (e.g., eluforsen QR-010)
Suspensions including liposomal formulations (e.g., liposomal amikacin, liposomal cyclosporine A)

The eFlow® Technology platform concept provides ...

Cost and time efficiency

Due to available customizable platform components

Low development efforts
High flexibility
Short lead times

Premium device quality

Due to extensive experience in aerosols

Efficiency – high fraction of filled volume deposits in target lung region
Optimized nebulization time (even for challenging formulations)

PARI’s engineers design solutions to adapt the eFlow® Technology platform to various needs of specific drug products, applications, and patient populations — Overview eFlow Technology Platform

The eFlow^® Technology nebulizer system (Open System) and its unique components.

eFlow® Open System Nebuliser (Drug-Specific)

eFlow^® Open System Nebulizer

eFlow® Closed System Nebuliser (Drug-Specific)

eFlow^® Closed System Nebulizer

eTrack® Controller & PARItrack® web portal

e-Health

eFlow^® Inline Nebulizer

eFlow Technology nebulizers with digital therapy management

Learn how the PARI Connect system supports patients with carefully considered device usability and digital therapy management solutions.

YOUR innovative aerosol therapy – OUR drug-nebulizer expertise

Watch five short expert interviews containing all you need to know about our partnering approach for pharmaceutical companies.

Developing new drug-nebulizer combination products

Learn more about the critical success factors and opportunities for bringing a new vibrating membrane nebulizer as a drug-device combination product to the market.

Do you have any questions about our technology, partnering approach and services?

Please contact us!
eFlow-partneringpari.com