In order to meet patients´ need for silent, fast and efficient delivery of aerosolised liquid drug products, PARI developed the eFlow Technology platform. A core component of all eFlow Technology nebulisers is a laser drilled, vibrating stainless steel membrane. Using a tightly controlled laser drilling process, the geometry of the holes in the membrane can be adjusted to produce aerosols with specific characteristics for optimised respiratory delivery.
All eFlow Technology nebulisers for spontaneously breathing patients utilise a patented mixing chamber with inhalation and exhalation valves. The aerosol is generated continuously into this chamber. During the inhalation phase, the aerosol is inhaled as emitted from the vibrating membrane while it is stored in the mixing chamber during the expiration phase. The stored aerosol is inhaled as a dense aerosol bolus at the onset of the following inspiration. This design reduces nebulisation time and increases delivery efficiency as the aerosol produced during the exhalation phase is largely conserved and also delivered to the patient.
Functionality of the mixing chamber
PARI’s engineers design solutions to adapt the eFlow® Technology platform to various needs of specific drug products, applications and patient populations. This includes options to tailor the nebuliser to:
Overview eFlow® Technology platform
Both the eFlow® and Vibrent® Technology can be adjusted to successfully nebulise a variety of molecules and formulations with a broad range of fill volumes and physicochemical properties, including: