News

Wednesday, 09. January 2013

PARI PEP System in combination with hypertonic saline...

...improves adherence in CF-patients

Hypertonic saline and positive expiratory pressure (PEP PEP
PEP: Positive expiratory pressure. By breathing out with a moderate force through a resistance, a positive pressure is generated in the airways, helping to keep them open. This positive pressure allows airflow to get beneath the areas of mucus obstruction and move the mucus toward the larger airways, where it can be coughed out.
) are well established therapies to support the mobilization of sputum sputum
Sputum is mucus that is coughed up from the lower airways.
in cystic fibrosis cystic fibrosis
Genetic disorder that affects most critically the lungs, leading to thick, viscous secretions.
(CF). In addition this combined approach of PEP PEP
PEP: Positive expiratory pressure. By breathing out with a moderate force through a resistance, a positive pressure is generated in the airways, helping to keep them open. This positive pressure allows airflow to get beneath the areas of mucus obstruction and move the mucus toward the larger airways, where it can be coughed out.
with nebulizer therapy has also shown to improve the tolerability of 6% hypertonic saline [1].

Active airway clearance techniques like the use of the PEP PEP
PEP: Positive expiratory pressure. By breathing out with a moderate force through a resistance, a positive pressure is generated in the airways, helping to keep them open. This positive pressure allows airflow to get beneath the areas of mucus obstruction and move the mucus toward the larger airways, where it can be coughed out.
system are considered as an integral component in the management of CF, but the exercises take time. One possibility to improve patient adherence is combining the PEP PEP
PEP: Positive expiratory pressure. By breathing out with a moderate force through a resistance, a positive pressure is generated in the airways, helping to keep them open. This positive pressure allows airflow to get beneath the areas of mucus obstruction and move the mucus toward the larger airways, where it can be coughed out.
therapy with nebulizers.

But how is the real life situation?

Therefore a new study [2] evaluated seventeen CF patients (mean age 13.1 years) who had self-reported poor adherence.

According to patients’ self-assessment, the combination of PARI PEP® System and HS led to the following advantages during 6 months of treatment time:

Improved:

·         amount of expectorated sputum sputum
Sputum is mucus that is coughed up from the lower airways.
in 94% of patients

·         treatment time in 82% of patients

·         adherence to physiotherapy in 77% of patients

All patients chose to continue the combined therapy until the end of the study.

Conclusion:

Even CF patients who struggled with treatment adherence, considered the combined therapy to be more effective.

Due to the high treatment burden of CF patients, this time-safe therapy combination has shown to be tailored for the needs of a CF-patient even in self-reported non-adherence patients!

Therefore the PARI PEP System together with a PARI nebulizer offers a convenient and simple tool to make the most of this advantage.

[1] 0’Connell et al. Respir Care. 2011 Jun; 56(6):771-5
[2] Elliot et al. 2012. NACF abtract 393