NewsMonday, 19. December 2011
Hypertonic saline solution – the only clinically effective treatment for bronchiolitis
The effectiveness of nebulised 3% saline solution – when used either in isolation or in combination with substances that dilate the bronchioles – was previously confirmed in a Cochrane Review in 20081. Various studies conducted on a sample of almost 600 patients demonstrated the positive effect of 3% saline solution as a treatment for bronchiolitis (inflammation of the bronchioles, the tiniest branches of the bronchial tree)2,3.
Now, the ERS/ISAM Task Force has confirmed, in its new guidelines for inhalation therapies, that 3% hypertonic saline solution is the only agent to be clinically effective in the treatment of bronchiolitis. Nebulisation with a 3% saline solution, administered on an in-patient or out-patient basis, resulted in a direct alleviation of the symptoms of bronchiolitis4.Hospital stays were also significantly shortened2,5.
The solution from PARI is MucoClear 3%.
*Eur Respir J. 2011 Jun;37(6):1308-31.Epub 2011 Feb 10.
Fig. 1: The young bronchiolitis patients showed considerable improvement after just 30 minutes of inhalation therapy with 3% saline solution. (n=52 Ø 2.9 ± 2.1 months). The difference between this outcome and the results from the control group is significant4
 Zhang et al. Cochrane Database; Syst. Rev. 2008; 8(4), CD 006458
Sarell et al. Chest. 2002; 122(6): 2015
 Grewal et al. Arch Pediatr Adolesc Med. 2009; 163(11):1007-1012
 Mandelberg et al. Chest. 2003; 123(2):48
 Tal et al. Med Assoc J 2006;8(3):169