News

Wednesday, 07. November 2012

First study shows: Hypertonic saline improves...

...clinical outcomes in preschoolers with acute wheezing wheezing
pfeifendes Atemgeräusch

The research group of Dr. Mandelberg showed firstly in a randomized trial that preschool children with acute wheezing wheezing
pfeifendes Atemgeräusch
have a shorter stay in the emergency department (ED) and are less likely to be hospitalized if their treatment includes inhaled hypertonic saline (HS)1.

Virus-induced wheezing wheezing
pfeifendes Atemgeräusch
is a common cause of emergency department visits for children. Symptoms like shortness of breath and difficulty of exhaling often do not respond well to common treatments like bronchodilators and corticosteroids2.

HS is already an established therapeutic approach in the treatment of cystic fibrosis cystic fibrosis
Genetic disorder that affects most critically the lungs, leading to thick, viscous secretions.
(CF). Therefore Ater et al. evaluated the effect of hypertonic saline in the new indication of wheezing wheezing
pfeifendes Atemgeräusch
preschool children.

The study involved 41 children ranging in age from 1-6 years (mean age 31.9 months) visiting the ED with acute wheezing wheezing
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episodes.

Children were randomized to inhale 5% hypertonic saline 4 ml mixed with albuterol (HS group) or normal saline 4 ml mixed with albuterol (NS group) twice every 20 minutes and then 4 times daily if the child was hospitalized.

Conclusion:

  • The admission rate to the hospital decreased significantly in the HS group vs. NS group (62.2% vs. 92%); p<0.05
  • Length of hospital stay in the HS-group decreased significantly (2 vs. 3 days); p=0.027
  • Both groups showed comparable and significant improvements of the clinical score (validated score for wheezing wheezing
    pfeifendes Atemgeräusch
    symptoms)

Diagramm - Alter

The admission rate was significantly lower in the HS-group than in the NS group: 62.2% vs. 92% (p<0.05)1

This study successfully introduced the use of hypertonic saline in the therapy of wheezing wheezing
pfeifendes Atemgeräusch
children. Hypertonic saline helped to reduce significantly the admission rate and length of hospital stay. Although more studies are needed, hypertonic saline has the potential to become an important option even for the treatment of acute wheezing wheezing
pfeifendes Atemgeräusch
.

1 Ater et al; Pediatrics 2012 Jun;129(6):e1397-403
2 Panickar et al; N Engl J Med. 2009 Jan 22;360(4):329-38