News

Friday, 19. July 2013

Considerable differences in lung dose of nebulisers in children

The well proven PARI LC SPRINT Junior/JuniorBOY SX system keeps to be the best choice for effective delivering of Salbutamol in children.

The careful choice of the inhalation device is a crucial factor for the efficient pulmonary delivery of drugs in children. This was the conclusion of the poster of Prof. Kamin and his team presented at the annual meeting of the Society for Pediatric Pneumology Pneumology
Pulmonology is the medical specialty dealing with disease involving the respiratory tract.
in Lübeck.

The objective of this in-vitro study was to evaluate the aerosol aerosol
An aerosol is a colloid of fine solid particles or liquid droplets, in air or another gas.
performance of 5 relevant jet nebuliser-compressor-systems for children on the German market. Therefore Salbutamol (Sultanol forte 2.5 mg/2.5 ml) was nebulised in two simulation models.

Respirable Drug Delivery Rate Respirable Drug Delivery Rate
The amount of respirable drug that is supplied at the mouthpiece per minute.
(RDDR RDDR
The amount of respirable drug that is supplied at the mouthpiece per minute.
) is considered as the most meaningful parameter that describes the amount of respirable drug that is supplied at the mouthpiece per minute. For children a nebuliser with a high RDDR RDDR
The amount of respirable drug that is supplied at the mouthpiece per minute.
should be selected in order to ensure the best possible therapeutic outcome and adherence.

Diagramm - Kamin

Fig 1: The RDDR RDDR
The amount of respirable drug that is supplied at the mouthpiece per minute.
for particles < 3,3 µm (relevant particle size for aerosol aerosol
An aerosol is a colloid of fine solid particles or liquid droplets, in air or another gas.
therapy in children) was four times higher for the LC SPRINT Junior/JuniorBOY SX system than for the AmpollaNebjet/MIDINEB system, that presented the lowest value(n=4).

The in-vitro lung dose of the 5 nebulisers varies widely in the presented standardized simulation model mimicking a children´s breathing pattern (Fig. 1). The well proven PARI LC SPRINT Junior/JuniorBOY SX system keeps to be the best choice for effective delivering of Salbutamol in children.

Walz-Jung et al. Poster; 35. Jahrestagung der Gesellschaft für pädiatrische Pneumologie Pneumologie
Lehre von den Erkrankungen der Atmungsorgane.
2013