NewsFriday, 19. July 2013
Considerable differences in lung dose of nebulisers in children
The careful choice of the inhalation device is a crucial factor for the efficient pulmonary delivery of drugs in children. This was the conclusion of the poster of Prof. Kamin and his team presented at the annual meeting of the Society for Pediatric Pneumology in Lübeck.
The objective of this in-vitro study was to evaluate the aerosol performance of 5 relevant jet nebuliser-compressor-systems for children on the German market. Therefore Salbutamol (Sultanol forte 2.5 mg/2.5 ml) was nebulised in two simulation models.
Respirable Drug Delivery Rate (RDDR) is considered as the most meaningful parameter that describes the amount of respirable drug that is supplied at the mouthpiece per minute. For children a nebuliser with a high RDDR should be selected in order to ensure the best possible therapeutic outcome and adherence.
Fig 1: The RDDR for particles < 3,3 µm (relevant particle size for aerosol therapy in children) was four times higher for the LC SPRINT Junior/JuniorBOY SX system than for the AmpollaNebjet/MIDINEB system, that presented the lowest value(n=4).
The in-vitro lung dose of the 5 nebulisers varies widely in the presented standardized simulation model mimicking a children´s breathing pattern (Fig. 1). The well proven PARI LC SPRINT Junior/JuniorBOY SX system keeps to be the best choice for effective delivering of Salbutamol in children.
Walz-Jung et al. Poster; 35. Jahrestagung der Gesellschaft für pädiatrische Pneumologie 2013