NewsMonday, 28. January 2013
The inhalation of corticosteroids with the PARI SINUS seems to enhance the effect of the topical application of the drug. This is shown in the results of a pilot study published at the 83rd Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery 2012.
Hanga et al treated 7 patients with chronic rhinosinusitis (without polyps) with a corticosteroid. The ENT-specialists from Heidelberg, Germany had their patients inhale Fluticasonpropionat (Flutide forte, 2mg/2ml Suspension) once a day for 6 weeks with PARI SINUS, a device developed specially for the treatment of the paranasal sinuses.
The sinunasal outcome test (German version of the SNOT 20) values taken before and after the therapy cycle, as well as the thickness of the mucosa in the maxillary sinus, gave cause for optimism. The subjective evaluation of impairment resulting from the illness sank from 6.9 to 4.7 (- 32%) on a scale of 0-10. The average mucosa thickness of the medial wall in the left maxillary sinus decreased from 4,2 mm to 2,8 mm (-33%)
This very positive result is because the vibrating aerosol delivers the drug into the paranasal sinuses – allowing the drug to have its anti-inflammatory effect exactly where needed, at the point of disease.
Despite the fact that this pilot study included only a few patients, its results give hope to CRS patients. If these results can be confirmed in a further study with a considerably higher number of patients, they would open further doors for this non-invasive and almost painless therapy option.
Patient's subjective validation of the impairment caused by the disease on a 1-10 scale before and after the therapy.
Thickness of the mucosa in the left maxillary sinus before and after the therapy.
Hanga Darinka, Baumann I, Rohde S, Schipper J. (2012): Vibrations-Inhalation von Fluticasonpropionat bei chronischer Rhinosinusitis mit dem Pari Sinus – eine Pilotstudie. Vortrag zur 83. Jahrestagung der deutschen Gesellschaft für Hals-Nasen-Ohren Heilkunde, Kopf- und Halschirurgie, 16.-20.05.2012, Mainz.